THE EFFECT OF HPMC AS A GEL BASE AND TWEEN 80 SPAN 80 COMBINATIONS AS EMULGATORS IN ACETOSAL TRANSDERMAL EMULGEL PREPARATIONS
Acetosal or acetyl salicylic acid is a drug that has efficacy as ananalgesic, antipireic, and antiplatelet.Aacetosal undegoes cross-first metabolisism (first pass effect) causing low drug bioavailability.The smal lsolubility of acetosal will affect the rate of absorption which later affect the intensity of treatment, so transdermal delivery in emul